b'@article{Schlicker_BMCBioinformatics_2006,'b'\nTITLE = {A New Measure for Functional Similarity of Gene Products based on Gene Ontology},\nAUTHOR = {Schlicker, Andreas and Domingues, Francisco S. and Rahnenf{\\"u}hrer, J{\\"o}rg and Lengauer, Thomas},\nLANGUAGE = {eng},\nISSN = {1471-2105},\nDOI = {10.1186/1471-2105-7-302},\nLOCALID = {Local-ID: C125673F004B2D7B-BF59AAAC3C285FAEC12571F500572B63-Schlicker_BMCBioinformatics_2006},\nPUBLISHER = {BioMed Central},\nYEAR = {2006},\nDATE = {2006},\nABSTRACT = {\\paragraph*{Background:} Gene Ontology (GO) is a standard vocabulary of<br>functional terms and allows<br>for coherent annotation of gene products. These annotations provide a basis for<br>new methods that compare gene products regarding their molecular function and<br>biological role. <br> <br> \\paragraph*{Results:} We present a new method for comparing sets of GO<br>terms and for assessing the functional similarity of gene products. The method<br>relies on two semantic similarity measures; ${\\textit sim_{Rel}}$ and ${\\textit<br>funSim}$. One measure (${\\textit sim_{Rel}}$) is applied in the comparison of<br>the biological processes found in different groups of organisms. The other<br>measure (${\\textit funSim}$) is used to find functionally related gene products<br>within the same or between different genomes. Results indicate that the method,<br>in addition to being in good agreement with established sequence similarity<br>approaches, also provides a means for the identification of functionally related<br>proteins independent of evolutionary relationships. The method is also applied<br>to estimating functional similarity between all proteins in Saccharomyces<br>cerevisiae and to visualizing the molecular function space of yeast in a map of<br>the functional space. A similar approach is used to visualize the functional<br>relationships between protein families.<br><br> \\paragraph*{Conclusions:} The approach enables the comparison of the<br>underlying molecular biology of different taxonomic groups and provides a new<br>comparative genomics tool identifying functionally related gene products<br>independent of homology. The proposed map of the functional space provides a new<br>global view on the functional relationships between gene products or protein<br>families.},\nJOURNAL = {BMC Bioinformatics},\nVOLUME = {7},\nPAGES = {1--16},\nEID = {302},\n}\n'